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Obesity, Herbal Supplements, and Weight Loss: A Narrative Review of Efficacy and Safety

Elif Didem ÖRS DEMET,zeynep Göktaş

  • zeynep Göktaş: HACETTEPE ÜNİVERSİTESİ
  •  Yıl : 2025
  •  Cilt : 3
  •  Sayı : 2
  •  Sayfa : 175-197
Obezite ve buna eşlik eden komorbiditeler, günümüzde küresel ölçekte önemli bir halk sağlığı sorunu haline gelmiş ve sağlık sistemleri ile sosyoekonomik yapılar üzerinde ciddi bir yük oluşturmuştur. Sağlıklı beslenme düzeni, düzenli fiziksel aktivite ve davranışsal yaklaşımları içeren yaşam tarzı değişiklikleri vücut ağırlığı yönetiminin temelini oluştursa da, uzun dönemli uyumun yetersiz olması bireyleri sıklıkla alternatif stratejilere yöneltmektedir. Bu bağlamda, bitkisel takviyeler, iddia edilen anti-obezite özellikleri nedeniyle yaygın olarak kullanılmaktadır.Bu anlatımsal derleme, yaygın olarak kullanılan bazı bitkisel takviyelerin etki mekanizmalarını, etkinliklerini ve güvenlik profillerini incelemektedir. Zencefil, termojenez ve iştah düzenlenmesi ile ilişkilendirilmiş olsa da mevcut bulgular tutarsızdır. Karahindiba antioksidan ve anti-adipojenik özellikler göstermekte, ancak bu etkileri doğrulayan insan çalışmaları sınırlıdır. Garcinia cambogia kısa vadede mütevazı bir vücut ağırlığı kaybı sağlayabilmekte, buna karşın hepatotoksisiteye ilişkin endişeler devam etmektedir. Guar gam ve kısmen hidrolize guar gam tokluk hissini artırabilir ve lipid profillerini iyileştirebilir; ancak uzun dönem vücut ağırlığı kontrolündeki rolleri net değildir. Guarana ve yerba mate, kafein ve polifenol içerikleri sayesinde metabolik ve kardiyovasküler faydalar sunabilir, ancak bu etkilerin doğrulanması için ek klinik kanıtlara ihtiyaç vardır. Opuntia ficus-indica lif özleri, dışkı yoluyla yağ atımını artırarak mütevazı kilo kaybına katkıda bulunabilirken, gastrointestinal yan etkiler bildirilmiştir. Yeşil çay ve özellikle epigallokateşin-3-gallat (EGCG), adipogenez ve enerji metabolizmasını etkileyen çoklu mekanizmalar sergilemekte olup, hepatotoksisite esas olarak yoğunlaştırılmış ekstrelerle ilişkilendirilmektedir. Genel olarak, bu takviyeler çeşitli biyolojik aktiviteler gösterse de, vücut ağırlığı yönetiminde uzun vadeli etkinliklerini destekleyen kanıtlar sınırlıdır. Obezitenin önlenmesi ve tedavisinde sürdürülebilir yaşam tarzı değişiklikleri en güvenilir ve etkili strateji olmaya devam etmektedir.
Atıf yapmak için : Örs Demet, E.D., Göktaş, Z. (2024). Obesity, herbal supplements, and weight loss: A narrative review of efficacy and safety. Sustainable Welfare, 3(2), 175-197.

Çıkar İlişkisi : Yazarlar çıkar çatışması olmadığını beyan etmiştir.

Bu makale CC BY-NC 4.0 lisansı ile yayımlanmıştır.
Sustainable Welfare
2025, Cilt3, Sayı2
ISSN: 3023-6673
Geliş Tarihi : , Kabul Tarihi : , Yayın Tarihi :

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